KCRM is totally dedicated to research and is on the forefront of the latest technology. In our pursuit of excellence, we have developed many innovative techniques and products. We present our research to the international scientific community on a regular basis, in the form of either abstracts at conference meetings or as publications in international reviewed journals. Our abstract presentations and journal publications are listed below.





Zavos, P.M., Correa, J.R., Zarmakoupis-Zavos, P.N.: Antisperm antibody treatment mode: levels of antisperm antibodies following incubation in TEST-Yolk buffer and filtration via the SpermPrep II method. Fertility and Sterility, 69(3):517-21, 1998. 



Toda, T., Sofikitis, N., Miyagawa, I., Zavos, P.M., Harada, T., Mio, Y. and Terakawa, N.:  Hypoosmotic swelling test / acrosin activity assay: Identifying subpopulations of idiopathic infertile men.  Molecular Andrology. 4:147-148, 1992. 

Sofikitis, N., Miyagawa, I. and Zavos, P.M.: Capacitation/acrosome reaction and outcome of hypoosmotic swelling test in human sperm. Molecular Andrology. 4:363-368, 1992.



Zarmakoupis-Zavos, P.N., Zavos, P.M.:Can the method of sperm preparation for intrauterine insemination affect subsequent pregnancy rates? Comparisons between the SpermPrepTM and the traditional double wash method. Middle East Fertility Society Journal, 3(2):164-170, 1998. 

Zavos, P.M., Zarmakoupis-Zavos, P.N. Correa, J.R., Abouabdallah, M. Aslanis, P. : Variations in pregnancy rates following intrauterine insemination among fertility centers: can the inseminators make a difference?  Middle East Fertility Society Journal. 2(1):24-29, 1997. 

Zavos, P.M.: Is intra-uterine insemination using husband's semen still a valid  option for the treatment of the fertile couple? Middle East Fertility Society  Journal, 2(3):208-2l0, 1997. 



Zarmakoupis-Zavos, P.N., Correa, J.R., Zarmakoupis,C.N., Zavos, P.M.: Multiple ejaculate collection via the use of a seminal collection device at intercourse vs masturbation.  Middle East Fertility Society Journal, 3(3):1-5, 1998. 

Zavos, P.M.:  Characteristics of human ejaculates collected via masturbation and a new Silastic seminal fluid collection device (SCD).  Fertil. Steril., 43(3):491-492, 1985. 

Zavos, P.M.:  Seminal parameters of ejaculates collected from oligospermic and normospermic patients via masturbation and at intercourse with the use of a Silastic seminal fluid collection device.  Fertil. Steril.,  44(4):517-520, 1985. 

Zavos, P.M.:  Comparisons between ejaculates collected at intercourse and at masturbation.  Young Couples International, 2:5, 1985. 

Zavos, P.M.:  Parameters and improvements in ejaculates collected at intercourse and the use of a silastic seminal collection device vs masturbation.  Infertility,  9(1):57-64, 1986. 

Zavos, P.M.:  Qualitative and quantitative seminal losses during production of ejaculates via masturbation.  Infertility, 9(2):153-160, 1986. 

Zavos, P.M.:  Treatment of ejaculatory and spermatogenic dysfunctions in oligospermic patients via collection of ejaculates at intercourse using a seminal fluid collection device.  Infertility,  10(2):167-171, 1987. 

Zavos, P.M., Goodpasture, J.C.:  Clinical use of a seminal collection device:  improvements of specific seminal deficiencies through use of a seminal collection device at intercourse versus masturbation.  Infertility, 11(4):289-304, 1988. 

Zavos, P.M. and Goodpasture, J.C.:  Clinical improvements of specific seminal deficiencies via intercourse with a seminal collection device versus masturbation.  Fertil. Steril.  51(1):190-193, 1989. 

Zavos, P.M.:  New seminal collection devices.  Resolve.  25(1):2, 1990. 



Zavos, P.M.:  Cervical mucus pH and the fractional postcoital test.  Infertility,  8:139-151, 1985.



Kofinas, G.D. and Zavos, P.M.: Retrograde ejaculation: preparation of spermatozoa for insemination from retrograde ejaculates using the new SpermPrep filtration method. Molecular Andrology. 4:121-126, 1992. 

Zavos, P.M. and Wilson, E. A.:  Retrograde ejaculation:  A new technique for collection and reconstitution of retrograde ejaculate.  Infertility, 5(4):287-296, 1983. 

Zavos, P.M. and Wilson, E.A.:  Recovery of retrograde ejaculates fit for AI via the use of a low risk method.  Young Couples International, 2:2, 1984. 

Zavos, P.M. and Wilson, E.A.:  Retrograde ejaculation:  etiology and treatment via the use of a new noninvasive method.  Fertil. Steril., 42(4):627-632, 1984. 



Zavos, P.M., Barnes, F.L., Correa, J.R., Zarmakoupis-Zavos, P.N., Tesarik, J.: Methods for isolation and purification of post-ejaculate human round spermatids for possible use in intracytoplasmic round spermatid injection. Middle East Fertility Society Journal. 2:147-150, 1997. 



Zavos, P.M., Goodpasture, J.C. and Zaneveld, L.J.D.:  The effect of temperature on sperm motility and viability.  Fertil. Steril., 36(2):254, 1981. 

Zavos, P.M., Zarmakoupis-Zavos, P.N., Correa, J.R., Antypas, S., Aslanis, P., Zarmakoupis, C.N.: The inability to produce seminal specimens at the time of seminal evaluation may reflect difficulties with sexual drive and deficient spermatogenic parameters.  Middle East Fertility Society Journal, 3(3): 352-356,1998 



Zavos, P.M., Correa, J.R., Sofikitis, N., Kofinas, G.D., Zarmakoupis, P.N.:   A method of short-term cyrostorage and selection of viable sperm for use in  the various assisted reproductive techniques.  Tohoku Journal of Experimental Medicine. 176:75-81, 1995. 

Zavos, P.M.:  Principles of cryopreservation of human spermatozoa; State of the art.  Infertility. 13(3-4):239-246, 1991. 



Sofikitis, N., Miyagawa ,I., Demetriadis, D., Zavos, P., Sikka, S.,  Hellstrom, W.:  Effect of smoking on testicular function, semen quality and sperm fertilizing capacity.  The Journal of Urology. 154:1-5, 1995. 

Zavos, P.M., Zarmakoupis, P.N., Antypas, S.C., Sofikitis, N., Kofinas, G.D., Miyagawa, I.:    Effect of cigarette smoking on the female reproductive health.  Adolescence Gynecology and Reproductive Menopause. 8(2):125-131, 1996. 

Zavos, P.M.:  Cigarette smoking and human reproduction: Effects on female and male fertility.  Kentucky Medical News. 2(8):5-6, 1996. 

Zavos, P.M., Correa, J.R., Antypas, S., Zarmakoupis-Zavos, P.N.,  Zarmakoupis C.N.: The effects of seminal plasma from cigarette smokers on sperm viability and longevity. Fertility and Sterility, 69(3):425-429, 1998. 

Zavos, P.M., Correa, J.R., Karagounis, C.S., Ahparaki, A., Phoroglou, C.R., Hicks, C.H., Zarmakoupis-Zavos, P.N.: An electron microscope study of the axonemal ultrastructure in human spermatozoa from smoking and nonsmoking males. Fertility and Sterility, 69(3):430-434, 1998. 

Zavos, P.M., Zarmakoupis,C.N. and Zarmakoupis-Zavos, P.N.:The impact of cigarette smoking on human reproduction: its effects on female and male fecundity. Middle East Fertility Society Journal, 3(3):340-47, 1998. 
 
Karagounis, S.C., Papanikolaou, N.A. and Zavos, P.M.:  Semen parameters compared between smoking and non-smoking men:  smoking intensity and semen parameters.  Infertility,  8(4): 373-382, 1985. 

Zavos, P.M.:  Cigarette smoking and human reproduction:  Effects on female and male fecundity.  Infertility 12(1):35-46, 1989. 



Zavos, P.M., Sofikitis, N., Toda, T. and Miyagawa, I.: Selection and preparation of human spermatozoa for artificial insemination using the new and improved SpermPrepII filtration method.  Japan J. Fertility Sterility. 37(3):14-19, 1992. 

Zavos, P.M.:  Preparation of human frozen-thawed specimens using the SpermPrep filtration method:  Improvements over the conventional swim-up method.  Fertility and Sterility. 57(6):1326-1330, 1992. 

Zavos, P.M.: Improvements in qualitative and quantitative characteristics of human spermatozoa using the Swim-up method and a new standardized Rise-Kit technique. Molecular Andrology. 4:231-239, 1992. 

Kofinas, G.D. and Zavos, P.M.: Preparation of sperm from patients with spermatogenic deficiencies for IUI purposes using the new/improved SpermPrep filtration. Molecular Andrology. 4:57-61, 1992. 

Zarmakoupis-Zavos, P.N., Zavos, P.M.:Can the method of sperm preparation for intrauterine insemination affect subsequent pregnancy rates? Comparisons between the SpermPrepTM and the traditional double wash method. Middle East Fertility Society Journal, 3(2):164-170, 1998. 

Zavos, P.M. and Centola, G.M.:  Qualitative and quantitative improvements in human spermatozoa recovered via the swim-up and a new semen filtration column (SCF) method.  Infertility, 13(1):25-34, 1990. 

Zavos, P.M. and Centola, G.M.: Selection of sperm from oligozoospermic men for ARTA: Comparisons between swim-up vs SpermPrep filtration.  J. Assisted Reproductive Technology-Andrology.  1:338-345, 1991. 

Centola, G.M. and Zavos, P.M.:  Qualitative/quantitative improvements in post-thaw human semen using SpermPrep .  J. Assisted Reproductive Technology-Andrology. 2:335-339, 1991. 

Zavos, P.M., Grove, R.J. and Rutz, E.M.:  Qualitative improvements of spermatozoa recovered through SpermPrep filter.  J. Assisted Reproductive Technology-Andrology. 2(2):206-207, 1991. 

Zavos, P.M., Sofikitis, N., Toda, T. and Miyagawa, I.: Improvements in qualitative characteristics of cryopreserved human spermatozoa following recovery via the SpermPrep II filtration method.  Tohoku J. Experimental Medicine. 163:283-290, 1991. 

Zavos, P.M.:  A new simple method for preparing spermatozoa for insemination using the new SpermPrep II filtration method.  J. Assisted Reproductive Technology-Andrology.  3:15-22, 1992. 



We have developed numerous products to help treat infertility problems, and market these internationally. For more information about our infertility products, please visit www.zdlinc.com
 



310 South Limestone Street, Lexington, KY 40503 USA
P.O. Box 23777 " Lexington, KY 40523 USA

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